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17 The retrospective study found that subcutaneous semaglutide use was statistically significantly associated with the risk of developing NAION, no matter what the medications reason for use: patients with type 2 diabetes had a 4.28 HR compared to control (n=17 vs 6), while patients who used the medications for weight loss had a 7.64 HR compared to control (n=20 vs 3)

Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats

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Vehicle-treated mice displayed severe islet disorganization and loss of insulin-positive -cells

PubMed , The American Journal of Clinical Nutrition , vol

(2010) NHS / UK Primary Care Pen Needle Guidance (2023) European Association for the Study of Diabetes (EASD) & American Diabetes Association (ADA) Manufacturer information for GLP-1 receptor agonists Diabetes UK