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Genetic factors in bile acid metabolism pathways, such as variations in the cytochrome P450 enzymes with CYP7A1 (cholesterol 7 alpha-hydroxylase), can alter bile acid synthesis and pool composition [48]

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Current opinion in rheumatology , 23 (5), 471

This is the central regulatory problem that full FDA approval would need to solve and it is the reason PCAC reviews for peptides like BPC-157 often hinge on available safety data rather than efficacy evidence from controlled human studies

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Por otra parte, TZP induce remisin de la esteatohepatitis asociada a disfuncin metablica (MASH) confirmada histolgicamente de forma dosis-dependiente (44-62% de casos, segn dosis) y mejora de al menos un estadio de fibrosis heptica en el 51-55% de los casos, cifras superiores a placebo45 (fig