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GHK-CU is a naturally occurring copper peptide complex formed when the tripeptide GHK binds with copper ions

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In some cases, this might lead to elevated liver enzymes or, less commonly, issues like pancreatitis

Stout JN, Lin P-Y, Sutin J, Higgins J, Grant PE (2022) Magnetic resonance imaging metrics of oxygen extraction fraction: Contradictions or insight into pathophysiological mechanisms

If taking higher doses, it is highly recommended to split the administration (e.g., one dose in the morning and one in the early afternoon) to maintain steady blood levels of the active compounds throughout the day