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(PubMed) Ellis JM, Kishi T, Azuma J, Folkers K

Based on data from the previous bioavailability study [27], the expected AUC 024h,SS treatment ratios (2G versus 1G) were 1.10 for group 1, and 1.08 for group 2 and group 3 and a coefficient of variation (CV) of 45% was considered reasonable

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The pharmacokinetics support once-weekly dosing thanks to a half-life of approximately 6 days, which means users can achieve consistent receptor activation without the peaks and valleys that destroy adherence

Researchers gradually increase to 4 mg, 8 mg, and 12 mg as tolerance develops