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Serum IL-8 levels were elevated in fibromyalgia patients as well, and these levels were reduced to near normal levels within 6 months after brief inpatient multidisciplinary pain therapy

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Increased levels of IL-1, IL-6, and TNF- further demonstrated systemic immune activation (Yang J.-Z

Following its nuclear localization, IGF-1R promotes TCF-mediated -catenin transcriptional activity, which has been confirmed in hepatocellular carcinoma cells (102)

Fibroblast Proliferation and Collagen Synthesis In the context of connective tissue repair, fibroblasts are critical for producing and remodeling the extracellular matrix, primarily through collagen synthesis