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Lyons J, Rauh-Pfeiffer A, Yu YM, Lu XM, Zurakowski D, Tompkins RG, Ajami AM, Young VR, Castillo L: Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet

5.1.4 Production of neurotransmitters The gut microbiota functions as an endocrine organ by producing various hormones and neurotransmitters that impact intestinal endocrine activity with the potential to regulate kidney function

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Importantly, human trials mirror this finding: months of regular endurance exercise in sedentary seniors increased muscle mitochondrial DNA, oxidative enzyme activities (citrate synthase, COX) and electron transport chain function ( These adaptations can be quite robust