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They usually diminish as the body adjusts, but in some cases, they can be persistent and severe enough to require discontinuation of the medication

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Jomova, K

Its ability to deliver high, conformal doses directly to the tumor while sparing surrounding organs makes it superior to external beam radiotherapy (EBRT) alone [10,11,12]

The cell lines, however, lose their BBB characteristics the more they are passaged, decreasing tight junction and transporter expression