For instance, while many of the GLP-1 drug interactions investigated to date may be statistically significant , no dose adjustment is required because they were not found to be clinically relevant . The one exception is tirzepatide, as described above
Antioxidants (Basel) 12(6):1171 Bermudez V et al (2010) PPAR- agonists and their role in type 2 diabetes mellitus management
After the exclusion of 9,075 patients due to prior anti-obesity medication, and 72,731 patients for bipolar, schizophrenia, depressive disorders, anxiety and suicide ideation or attempts within 1 year before, the treatment cohort numbered 162,257 patients
three of the clinical studies included a control group of individuals without GHD and three clinical studies were uncontrolled ( Table 2 )
American Family Physician, December 2017, pages 797-804 9
Tirzepatide may have serious side effects, including possible thyroid tumors