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The cisplatin bioactivating effect will be discussed further on in this paper

These changes are presented in more detail in Fig

Within the TME, exosomes convey bioactive messages in the form of nucleic acids (miRNA, mRNA, non-coding RNAs and mitochondrial DNA), proteins (cytokines, receptors and receptor ligands), metabolites and lipids, reflecting the metabolic state of the cells from which they are derived [136,137]