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Tregs produce inhibitory cytokines, kill effector cells via granzymes and perforins, and compete with effector T cells to deplete IL-2 [100]

This reveals that anti-PDLIM1 autoantibody can serve as the complementary measure for CA125, which can thereby improve OC detection power

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The disrupted microbiome interacts with host immunity through mechanisms such as impaired TLR signaling, persistent inflammasome activation, and excessive protease release, all of which degrade extracellular matrix and hinder re-epithelialization

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