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The KruskalWallis test was used to evaluate differences in gross morphological scores, histopathological scores, and lameness duration across all four treatment groups

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Viable cells (2.44.2 10 6 ) were pelleted and submitted to Azenta for RNA sequencing (paired-end, 30 million reads per sample)

In obese mice, combining ERR activation with dietary control yields additive improvements in fat mass and hepatic features, suggesting compatibility with lifestyle or other pharmacological interventions