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SLIMMER Phase 3 (ecnoglutide, 40 weeks): Key characteristics: Lowest discontinuation rate among the drugs compared here (~2%) GI events described as "mild-to-moderate" with no detailed breakdown of individual symptom rates publicly available The biased agonism profile may contribute to reduced severity of GI effects Discontinuation rates of 6-11% across dose groups (including all causes, not just AEs) Demonstrates that cAMP bias may translate to a clinically meaningful tolerability advantage CT-388# CT-388 is a signal-biased dual GLP-1/GIP receptor agonist developed by Roche/Genentech

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doi: 10.2337/dc13-0465 33 GutniakMOrskovCHolstJJAhrnBEfendicS