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This approach should be associated with the environmental one, which consists of reducing exposure to toxic substances and choosing a healthy lifestyle: a balanced diet, regular and moderate physical activity, and continuous stress management

To differentiate between the potential involvement of these two consequences in H 2 O 2 -induced sensitization to TNF hepatotoxicity, we first exposed HepG2 cells to (BSO), a potent inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the glutathione synthesis pathway (Fig

& Morgan, B

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