Consumers are often shocked to find that GLP-1 medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) can cost over $1,000 a month without insurance
Semaglutide is FDA-approved and widely available as branded medications
I kept my fingers crossed because I had seen the difference it made in my daughters life
On May 2, 2026, The Lancet published a randomized, double-blind, placebo-controlled trial (Klausen et al., Copenhagen University Hospital) testing once-weekly semaglutide 2.4 mg in 108 treatment-seeking adults with moderate to severe alcohol use disorder and comorbid obesity
FSA/HSA eligibility should be confirmed directly with TrimRx before assuming coverage
Other research highlights: 30% of GLP-1 users tested positive for SIBO or IMO even after accounting for diabetes (5) GLP-1 medicines caused microbiome changes and altered metabolism in mice (6) GLP-1 medicines tested in humans only had noticeable microbiome changes by 48 weeks (7) Despite not necessarily having slower gut motility, one study found that 88.9% of obese patients had SIBO (8) A meta analysis of people with IBS symptoms, found that up to 78% of people had SIBO, many of whom were undiagnosed (9) Overall, Sun and colleagues (1) could not prove a mechanistic link between GLP-1 medications and SIBO, however they did find that SIBO was twice as likely in GLP-1 users
