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Maintaining adequate hydration is important, as dehydration from gastrointestinal symptoms can increase the risk of acute kidney injury

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Several such studies are ongoing or planned, including those exploring weight management and metabolic support during therapy

A human retrospective cross-sectional analysis of 1477 women suggests that adequacy of dietary choline/betaine may be important for individuals with a lower folate intake or where the folate cycle is reduced due to SNPs or high alcohol consumption (lowering folate status) because the betaine-remethylation pathway of homocysteine is able to go someway to compensate for the folate re-methylation pathway (Chiuve et al , 2007)