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Research shows response varies significantly across individuals due to dose adequacy, adherence, metabolic factors, and genetic variation in GLP-1 receptor sensitivity

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About half report they have experienced nausea and around one-third have experienced diarrhoea the two most common side effects associated with GLP-1s

Instead, guidelines for Wegovy suggest starting with 0.25mg of semaglutide per week and then slowly going up to 2.4mg over the course of five months

As clinicians, were seeing real benefits from GLP-1 medications for the right patients especially where insulin resistance and obesity are driving disease but your caution is important

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