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Interestingly, tumours in mice treated with Hi + Ci exhibited a modest but significant reduction in collagen deposition compared to gemcitabine (Supplementary Fig

Cole SI, Chisholm D, Hughes J, Adams C, Callaghan D, Whiting A, Ambler C (2023) LXD191 is a novel, triple-action photosensitizer-histone deacetylase targeting inhibitor drug-drug conjugate: the efficient and selective killing of human oral cancer cells and animal tissue upon irradiation

This higher dose can be administered as a single 100mg injection in the morning or split into two 50mg doses taken 12 hours apart (morning and afternoon)

Some researchers find their optimal response at 1.0 mg or 1.7 mg

This is useful for researchers who need finer dosing control but do not need the extreme dilution of lower concentrations