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Croatian researcher Predrag Sikiric and colleagues at the University of Zagreb have published the bulk of the animal research over roughly three decades, with studies covering tendon healing, gastric ulceration, colitis, brain injury, and systemic organ protection in rodent models

The free tripeptide was first identified in human plasma in 1973 by Loren Pickart as a factor supporting cell proliferation in liver cell cultures, and the copper-binding role of the peptide was recognized shortly afterward as the molecular basis for many of the activities attributed to GHK

In fact, it often produces worse outcomes because severe nausea leads to dehydration, nutritional deficiency, and sometimes medication discontinuation

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