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Funding This research was funded by the National Institute of General Medical Sciences (P20GM121299-01) and National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (R15AR067451-01)

Together, these findings identify VadK as a regulatory kinase that integrates metabolic control with virulence in Mtb , revealing a new facet of metabolic regulation in bacterial pathogenesis and a potential target for therapeutic intervention