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FIGURE 4 Nuclear factor erythroid 2-related factor (NRF2) is an accepted master regulator participating in the cellular adaptive response to redox or energy stress, which accumulates in nuclear to induce a battery of defensive genes encoding detoxifying enzymes and antioxidant proteins (such as SOD2 and NFB) (Figure 4E) (Tonelli et al., 2018)

This is what the mechanistic description and variant should be based on ARG treated as a form that may change stability or formulation parameters, but requires separate validation

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a , e by two-tailed unpaired t -test