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The United Kingdoms National Health Service (NHS) notes that vitamin B12 deficiency is one possible cause of peripheral neuropathy, which people can treat by taking vitamin B12 supplements

In 2 compartment models, where the drug equilibrates between blood and (for example) adipose tissue, during elimination there is a sharp initial fall in blood levels followed by a gradual subsequent fall

However, this is controversial, and more evidence is needed

doi: 10.1186/cc7782

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