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Production of metabolites from amino acids, however, could play an important role in GLP-1 secretion from the colon, as the microbiota can ferment nutrients reaching the distal intestine (mostly colon) and produce metabolites, which may stimulate GLP-1 and PYY secretion [36,37,38]

Targeting Pre-Diabetes and Insulin Resistance Pre-diabetes is a condition where blood sugar levels are higher than normal but not high enough yet for a diagnosis of type 2 diabetes

Baseline and follow-up labs, unlimited provider visits, and medication coordination are commonly included in clinician-led telehealth programs

Focus on muscle preservation with protein and resistance training

5F), suggesting that intracellular Ca 2+ is indeed associated with the exendin-4 effect

If interventions are not started, the increased demand for insulin can overload pancreatic -cells leading to pancreatic -cell failure, decreased insulin secretion, and uncontrolled glycemia (Figure 1)