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30 Tretinoin alone, even without benzoyl peroxide, can degrade 60-80% when exposed to normal daylight over a period of 24 hours

Karz A, Dimitrova M, Kleffman K, Alvarez-Breckenridge C, Atkins MB, Boire A, Bosenberg M, Brastianos P, Cahill DP, Chen Q, Ferguson S, Forsyth P, Glitza Oliva IC, Goldberg SB, Holmen SL, Knisely JPS, Merlino G, Nguyen DX, Pacold ME, Perez-Guijarro E, Smalley KSM, Tawbi HA, Wen PY, Davies MA , Kluger HM, Mehnert JM, Hernando E

2008 Jan;134(1):166-178

doi: 10.3389/fphar.2021.774444 Received 12 September 2021 Accepted 20 December 2021 Published 17 January 2022 Volume 12 - 2021 Edited by Mariano Bizzarri, Sapienza University of Rome, Italy Reviewed by Mostafa Waly, Sultan Qaboos University, Oman Francis-Alfred Unuagbe Attah, University of Ilorin, Nigeria Updates Copyright 2022 Vyas, Kesari, Slama, Roychoudhury and Sisodia

Circulation

Avoid repeated freeze-thaw cycles if storing frozen