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While animal studies suggest promising benefits for tissue repair, inflammation reduction, and even gut health, human clinical research remains limited
The article lists the clinical goal as its own dosing consideration, noting that the objective may be weight loss, glucose control, appetite suppression, or cardiovascular benefit, and that each informs the strategy differently
But in rare cases, there can be more serious adverse reactions, including acute kidney injury
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Six enzymes of folic acid metabolism pathway were overexpressed, among which serine hydroxymethyltransferase 1 promoted the expression of cancer inflammatory factors by regulating sialic acid N-acetylneuraminic acid, and promoted the growth and metastasis of ovarian cancer tumor cells (69)
When symptoms do occur, they usually reflect underlying conditionssuch as liver disease, haematological disorders, or renal impairmentrather than the elevated vitamin itself
