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The main antidiabetic drugs used clinically are thiazolidinediones (e.g., troglitazone, rosiglitazone), metformin, sulphonylureas and glinides (10)
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Exendin-4, a glucagon-like peptide 1 receptor agonist, protects against amyloid- peptide-induced impairment of spatial learning and memory in rats
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Given their effectiveness in controlling blood glucose and HbA1c levels, with additional weight loss benefits and minimal intrinsic risk of hypoglycemic episodes, GLP-1 RAs are now considered the first-line injectables for optimal glucose control in diabetic patients even before insulin treatment [18]
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