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Apply one patch weekly to clean skin (upper arm, abdomen, thigh) for 4-8 hours

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It frames regain as a physiological effect: the medication mimics GLP-1 to signal fullness, and when it is withdrawn the body's own signaling may not fully compensate, so hunger and caloric intake rise

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A review and analysis of seven tirzepatide trials covering up to 72 weeks of treatment found that tirzepatide produced significant, dose-dependent weight loss, with the clearest results emerging as people moved into higher doses