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De Vincenzo R, Ferlini C, Distefano M, Gaggini C, Riva A, Bombardelli E, Morazzoni P, Valenti P, Belluti F, Ranelletti FO, Mancuso S, Scambia G (2000) In vitro evaluation of newly developed chalcone analogues in human cancer cells

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(PubMed) Zhou SJ, Skeaff SA, Ryan P, et al

These diurnal rhythm changes are also evident in at the level of cellular and organ metabolism ( Drug abuse related changes in metabolism would also have negative effects on various body systems due to increased cell damage, increased excitotoxicity, reduced energy production, and lowered antioxidant potential in cells