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Cardiac events included arrhythmias, hypertension, myocardial infarction, ischemic stroke and heart failure

SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase

The STEP trial program examining higher-dose semaglutide (2.4 mg weekly) for weight management demonstrated mean weight loss of 12% to 15% over 68 weeks in adults with obesity, significantly exceeding placebo

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