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The standard schedule begins at 0.3 mg weekly for four weeks, then escalates to 0.6 mg for four weeks, followed by 1.2 mg for four weeks, then 1.8 mg for four weeks, ultimately reaching the maintenance dose of 2.4 mg weekly

Such high-producing levels are of interest as this could theoretically be sufficient to meet daily needs of 1.6 mg riboflavin with one fermented beverage consumption of 100 mL, as validated by Spacova et al

According to a US national survey, the average dietary intake of vitamin B 12 is 5.9 g/day for adult men and 3.8 g/day for adult women

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10.3389/fcvm.2021.64113633718459 207 Nso N, Bookani KR, Metzl M, et al