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Indications: Guanethidine is no longer available in the USA due to lack of availability, but is available in the UK (wikipedia) Was used for severe cases of hypertension, either alone or as an adjunct drug Contraindications: Guanethidine can cause a hypertensive crisis in patients with pheochromocytoma due to the release of catecholamines (tyramine like action)

2 Contribution of Ferroptosis in Cardio-Cerebrovascular Disease As the maintenance of cardio-cerebrovascular homeostasis depends on CD and cell renewal, excessive cell loss will contribute to the occurrence of many CCVDs (Lu et al., 2020)

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