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The biologically active circulating form of GLP-1 is GLP-1 (7-36) amide, a 30-amino-acid peptide generated from post-translational processing of the proglucagon precursor and featuring a naturally occurring C-terminal amidation (-NH) [2]
However, the primary functions of PTMs of p53 in tumorigenesis-related ferroptosis have not been thoroughly reviewed in published literature
Because GLP-1 slows down digestion, some patients may experience mild gastrointestinal side effects like nausea, mild stomach discomfort, or changes in bowel habits, especially when first starting
As the majority of patients with type 2 diabetes are overweight or obese this offers a potential advantage over older, established therapies, and DPP-4 inhibitors are being used in clinical practice as second-line therapy in addition to metformin in overweight and obese patients who fail to reach glycemic targets with metformin monotherapy
However, the absence of a documented association does not mean the question is fully resolved
10.1146/annurev.pa.25.040185.003435 Ann Rev Pharmacol Toxicol
