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Development of a predictive enrichment marker for the oral GH secretagogue LUM-201 in pediatric growth hormone deficiency

While in the rd10 mouse photoreceptor death is completed in one month after birth, the photoreceptor degeneration in the Rho P23H/+ mouse progresses much slower and most photoreceptors are absent by 180 days of age

These and further adverse effects have been reported by the investigators using two IGF-I injections a day

Neither have been extensively studied, but most is known about GRP109a

doi: 10.1016/j.yrtph.2008.01.004

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