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Timing matters: take fat-soluble vitamins (A, D, E, K) with a small meal containing fat, separate B vitamins and iron by at least 2 hours, and avoid taking calcium within 4 hours of other supplements because it competes for absorption

Follow the same 16-week dose-increase schedule doctors use

Very spicy foods: Capsaicin and heavy spices can irritate an already sensitive digestive system

The comparison of basic laboratory profiles between supplement and placebo groups in each cohort at study enrollment and days 7, 14, and 21 were included in the secondary end points