Semaglutide and the family of GLP-1 analogues, including Wegovy, Ozempic, Rybelsus, Retatrutide, and Tirzepatide, have transformed the landscape of obesity treatment
7FIM: Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW
The fast losers are typically younger, have more weight to lose, started at higher body fat percentages, and often aren't training (meaning they're not preserving muscle, which makes the scale drop faster but the long-term outcome worse)
Now, a GLP-1 can replace metformin (with, for some, fewer side effects) or be taken together with metformin not only for the treatment of type 2 diabetes but also off-label for weight management
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Users who expected rapid changes in weight or appetite were often disappointed
