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244 Sheppard et al

Although rare, gallbladder cancer can be considered as a highly fatal complication of gallstones, since the tumour has a high grade of malignancy and diagnosis is often delayed, despite that it is an incidentaloma in 12% of cases during cholecystectomy [170, 171]

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Together, they serve as an experimental model for investigating parallel signaling pathways, receptor activation, and peptide synergy within endocrine systems