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Metabolite mapping revealed limited biotransformation: the major species in plasma remained intact parent peptide, with minor degradation products formed by endopeptidases rather than DPP-4, corroborating the in vitro stability data [44]

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2 Given the flaws in previous studies, amitriptyline cannot be recommended as the gold standard for treatment of fibromyalgia until further studies are conducted

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High-dose glutathione may interact with certain medications and is contraindicated in G6PD deficiency and some cancer populations