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Semaglutide : STEP 1 Phase 3 demonstrated 14.9% mean weight loss at 68 weeks with 2.4 mg weekly dose

According to the Summary of Product Characteristics (SmPC), severe gastrointestinal adverse reactions can lead to dehydration and, in rare cases, acute kidney injury

Nutrients 15:1913

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FTO rs9939609 and MC4R rs17782313 variants relate to metabolic regulation and satiety signaling

Using them together aims to provide the benefits of both sustained exposure and sharp pulses, potentially leading to superior outcomes in fat loss, muscle growth, and skin rejuvenation