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Oral contraceptives and serum-folate level
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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)
It has also been indicated that riboflavin deficiency decreases the mRNA level of antioxidant enzymes in muscle (GR, GPx, SOD and CAT) (Reference Jiang, Chen and Liu33) , intestine (GR, GPx and SOD) (Reference Chen, Feng and Jiang34) and gills (GR, SOD) (Reference Chen, Feng and Jiang35) of fish
3f, where it healed after being cut into two pieces and withstood bending force without cracking
