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Therapeutic potential of bioactive flavonoids from citrus fruit peels toward obesity and diabetes mellitus

If successful, survodutide could carve out a distinct clinical niche as the preferred metabolic peptide for patients with concurrent obesity and liver disease, complementing tirzepatide's established role in broader metabolic disease management

The least-squares mean percentage change in body weight at 24 weeks in the retatrutide groups was 7.2% in the 1-mg group, 12.9% in the combined 4-mg group, 17.3% in the combined 8-mg group, and 17.5% in the 12-mg group, as compared with 1.6% in the placebo group

The third receptor changes the metabolic profile in ways the other drugs cannot reproduce, particularly for liver fat and triglyceride handling

The success with GLP-1 drugs has also prompted researchers to start investigating in detail the physiology of GLP-1 in the gut and the brain

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