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Maintain a healthy, sustainable diet : Focusing on incorporating a variety of whole foods while consuming enough protein will assist in muscle retention and fat regulation

Faillie, J.-L

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In the meantime, mitochondrial dysfunction is induced by hepatic IR and lipid accumulation and the lipid peroxidation mediated by cytochrome p450 2E1 boost the production of reactive oxygen and promote the degradation of mitochondria (125), which could further lead to the lack of cellular energy and metabolic intermediates accumulation, all these may lead to the secretion of pro-inflammatory cytokines, hepatocellular apoptosis and hepatic fibrogenesis, finally resulting in cirrhosis of the liver (125) ( Figure 3 )