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P values were adjusted for multiple testing using the Bonferroni method (adjusting for the number of cell populations the number of modules)

Dose-finding studies for CNS effects in humans are needed because extrapolation from rat doses is unreliable

Growth Hormone & IGF Research , 2014 Showed upregulation of GH receptor expression in tendon fibroblasts, supporting connective tissue repair mechanisms

However, researchers acknowledge they are far from developing a clinical application

According to FDA labeling, metformin is indicated to improve glycemic control in adults and children aged 10 years and older with type 2 diabetes

doi:10.1016/j.bpobgyn.2026.102706