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Conversely, Wegovy is designed for weight loss (the dosing and regulatory approval are distinct)

Some people with UC struggle with unintentional weight loss during flares

Cagrilintide had one of the lowest GI odds ratios among incretin-class compounds in a 2025 network meta-analysis, but combination GI burden has not been formally quantified

Dysregulation of GHIGF-1 axis can amplify the synergistic effect of GH and IGF-1 to promote uncontrolled cell proliferation, cell movement, angiogenesis, and suppress apoptosis to increase risk of neoplasia (272)

Effect of baseline eGFR and UACR on risk of MACE regardless of treatment

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