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Acknowledgements This work was supported by NIH Grants GM102146 (M.J.S.), GM044100 (T.R.B.), and U19AI068021-06 (D.A.S.)

The anti-ferroptosis activity of -tocopherol is mediated by Alox15, a key enzyme responsible for the generation of 4-hydroxy-2-nonenal (4-HNE), one of the final products of lipid peroxidation (63, 64)

One study found GSH with meropenem disrupted glycerophospholipid metabolism and increased membrane permeability

On rare occasions, affecting fewer than 2% of subjects, both peptides may also cause minor to moderate hepatobiliary conditions, such as gallstones and acute pancreatitis

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