While the regulation of MTHFR activity is closely controlled by SAM at C-terminal regulatory domain, more studies indicated that the human MTHFR enzyme activity is also regulated by multiple phosphorylated sites on a serine-rich N-terminal extension region 20
By influencing hormonal signaling and aggregating in prostate tissue, they assist in regulating cell proliferation, inhibiting inflammation, and promoting apoptosis, so contributing to a potential chemopreventive impact against PCa
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This imbalance compromises cellular equilibrium and initiates inflammation, which is necessary for immune defense
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