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Subsequent haemodynamic assessments did not show any adverse effects of any of the treatments on heart rate or arterial blood pressure in lean mice receiving treatment for 14 days (Extended Data Fig

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Results from 8 randomized controlled trials (6 361 participants) indicated that these effects might last up to 3.5 years, although long-term safety data remain limited

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Parkinsons disease: Trials ongoing All-Cause Mortality: Overall death rate: 10-15% reduction in high-risk populations

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