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Overall, T-maze reversal performance was most highly correlated with GABA, glutamate and stress-related gene expression, as well as with miRNA expression levels, compared to other behavioral measures (Table S4)

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 10% by weight of the poloxamer

There is currently insufficient human clinical evidence for regulatory approval

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Characterizing the RNA targets and position-dependent splicing regulation by TDP-43

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