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Furthermore, our findings highlight the importance of using standardized techniques in preclinical and clinical research, particularly in the case of REDOX biology as shown here

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4.3 Anti-apoptotic mechanisms of hydrogen In addition to its antioxidant and anti-inflammatory properties, the hydrogen molecule exhibits significant anti-apoptotic effects, which have been extensively studied across various neurological disorders

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This review has delineated the anatomical and pathophysiological basis of rotator cuff-associated muscle atrophy, with a particular focus on the pivotal role of ROS in mediating oxidative damage, mitochondrial dysfunction, myofiber apoptosis, and activation of key catabolic signaling cascades, including the FOXO, NF-B, and MAPK pathways