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SGLT2 brain expression is lower compared to SGLT1, and it is localized mainly in the microvessels of the blood-brain barrier, in the amygdala, hypothalamus, periaqueductal gray, and in the dorsomedial medulla (Enerson and Drewes, 2006)

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Once glycogen runs out, the body switches to deriving energy from fat, inducing a metabolic state known as ketosis