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bmj.com/content/394/bm Associated editorial in @bmj_latest: bmj.com/content/394/bm Driven by this evidence, a new international trustworthy practice guidelines addressing pharmacotherapies for overweight and obesity is in development as part of the BMJ Rapid Recommendation series, led by MAGIC

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13 Inclusion criteria: The sample included adults (age 18 years) with 13 : 1 inpatient primary MS diagnosis or 2 outpatient MS diagnoses in any position 30 days apart in the 12 months prior to (preindex period) or 6 months following the index date First claims were recorded on or after the index date of August 20, 2020, and continuous enrollment in a commercial insurance plan 12 months before and 24 months after the index date The index date was defined as the date of the first KESIMPTA or Ocrevus claim, which was by design after the KESIMPTA US Food and Drug Administration approval on August 20, 2020 Optum Clinformatics Data Mart Database is a longitudinal database of medical and pharmacy administrative claims for patients enrolled in commercial insurance and Medicare Advantage plans in the United States

These structures occupy a uniquely powerful position in biology: they are too small to be classified as full proteins, yet too biologically active to be dismissed as simple building blocks