In clinical trials published in the New England Journal of Medicine 2022, tirzepatide showed much superior results to semaglutide in terms of reducing HbA1c and appropriately supporting weight loss
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Risk ratios (RR) for nonfatal myocardial infarction estimates according to direct (DPP-4 inhibitors, GLP-1RA and SGLT-2 inhibitors against placebo) and indirect (DPP-4 inhibitors vs GLP-1RA or SGLT-2 inhibitors, and GLP-1RA vs SGLT-2 inhibitors) comparisons
Together, these results highlight the importance of ECL1 in GLP-2 recognition and receptor activation
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Provides protection from free radical damage for the cells